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By Robert Anderson • Updated Sep 27, 2026 at 00:50
College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 4 - CBS Sports

Notable Week 4 Games: Iowa-Michigan and Oregon-USC

Week 4 of college football offers a series of notable matchups, such as the Iowa-Michigan game and the Oregon-USC contest. This week stands out for having the highest number of ranked games since 2023. Predictions and betting lines are available for the top 25 matchups. Live updates, schedules, and scores are tracked on NCAA.com. Donald Trump was present at a game with a plan to safeguard communications. Live broadcasts are available on SiriusXM and local stations.

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