The two clubs go head‑to‑head at the MCG on Saturday at 7.40pm.
Five players are out from Collingwood’s squad.
One player is still recovering after a car crash knocked out during practice.
North Melbourne’s VFL side defeated North’s youngsters last week by 43 points.
That win has provided the seniors boosted morale.
Both clubs want a strong beginning to the latter half of the season.